BDBM358081 ((2S,4R)-2-(3-(4-amino-5-(1-(tetrahydro-2H- pyran-4-yl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4] triazin-7-yl)phenyl)-4-hydroxypyrrolidin-1- yl)(pyridin-3-yl)methanone::US10214537, Example 150

SMILES: CC(C)[C@@H]1C[C@@H](O)CN1C(=O)c1cccnc1

InChI Key: InChIKey=UBUUNFPGICHHNJ-NEPJUHHUSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 358081   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM358081 (((2S,4R)-2-(3-(4-amino-5-(1-(tetrahydro-2H- pyran-...) Show SMILES CC(C)[C@@H]1C[C@@H](O)CN1C(=O)c1cccnc1 Show InChI InChI=1S/C13H18N2O2/c1-9(2)12-6-11(16)8-15(12)13(17)10-4-3-5-14-7-10/h3-5,7,9,11-12,16H,6,8H2,1-2H3/t11-,12+/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co. US Patent					Assay Description The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...				US Patent US10214537 (2019) BindingDB Entry DOI: 10.7270/Q2HH6NB2
					More data for this Ligand-Target Pair