BindingDB logo
myBDB logout

BDBM358081 ((2S,4R)-2-(3-(4-amino-5-(1-(tetrahydro-2H- pyran-4-yl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4] triazin-7-yl)phenyl)-4-hydroxypyrrolidin-1- yl)(pyridin-3-yl)methanone::US10214537, Example 150

SMILES: CC(C)[C@@H]1C[C@@H](O)CN1C(=O)c1cccnc1

InChI Key: InChIKey=UBUUNFPGICHHNJ-NEPJUHHUSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 358081   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM358081
PNG
(((2S,4R)-2-(3-(4-amino-5-(1-(tetrahydro-2H- pyran-...)
Show SMILES CC(C)[C@@H]1C[C@@H](O)CN1C(=O)c1cccnc1
Show InChI InChI=1S/C13H18N2O2/c1-9(2)12-6-11(16)8-15(12)13(17)10-4-3-5-14-7-10/h3-5,7,9,11-12,16H,6,8H2,1-2H3/t11-,12+/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...


US Patent US10214537 (2019)


BindingDB Entry DOI: 10.7270/Q2HH6NB2
More data for this
Ligand-Target Pair