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BDBM361615 US10221175, Compound 20

SMILES: Cc1nnc2ccc3CN(Cc4ccc(cc4F)-c4cc(C)c5nn(C)cc5c4)C(=O)c3n12

InChI Key: InChIKey=YWERFIBFEAXCJT-UHFFFAOYSA-N

Data: 1 EC50

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 361615   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM361615
PNG
(US10221175, Compound 20)
Show SMILES Cc1nnc2ccc3CN(Cc4ccc(cc4F)-c4cc(C)c5nn(C)cc5c4)C(=O)c3n12
Show InChI InChI=1S/C25H21FN6O/c1-14-8-19(9-20-11-30(3)29-23(14)20)16-4-5-17(21(26)10-16)12-31-13-18-6-7-22-28-27-15(2)32(22)24(18)25(31)33/h4-11H,12-13H2,1-3H3
Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.10E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10221175 (2019)


BindingDB Entry DOI: 10.7270/Q27W6FGP
More data for this
Ligand-Target Pair