BDBM361615 US10221175, Compound 20

SMILES: Cc1nnc2ccc3CN(Cc4ccc(cc4F)-c4cc(C)c5nn(C)cc5c4)C(=O)c3n12

InChI Key: InChIKey=YWERFIBFEAXCJT-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 361615   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM361615 (US10221175, Compound 20) Show SMILES Cc1nnc2ccc3CN(Cc4ccc(cc4F)-c4cc(C)c5nn(C)cc5c4)C(=O)c3n12 Show InChI InChI=1S/C25H21FN6O/c1-14-8-19(9-20-11-30(3)29-23(14)20)16-4-5-17(21(26)10-16)12-31-13-18-6-7-22-28-27-15(2)32(22)24(18)25(31)33/h4-11H,12-13H2,1-3H3	Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a
Vanderbilt University US Patent					Assay Description For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...				US Patent US10221175 (2019) BindingDB Entry DOI: 10.7270/Q27W6FGP
					More data for this Ligand-Target Pair