BindingDB logo
myBDB logout

BDBM363212 (2R,3S)-2-((2-((3-cyanobenzyl)oxy)-6-methoxy-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)-3-hydroxybutanoic acid::US9850225, Example 1135

SMILES: COc1cc(OCc2cccc(c2C)-c2ccccc2)cc(OCc2cccc(c2)C#N)c1CN[C@H]([C@H](C)O)C(O)=O

InChI Key: InChIKey=MWGTVYDWJRCRQT-FLASPHMUSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 363212   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Programmed cell death 1 ligand 1


(Homo sapiens (Human))
BDBM363212
PNG
((2R,3S)-2-((2-((3-cyanobenzyl)oxy)-6-methoxy-4-((2...)
Show SMILES COc1cc(OCc2cccc(c2C)-c2ccccc2)cc(OCc2cccc(c2)C#N)c1CN[C@H]([C@H](C)O)C(O)=O
Show InChI InChI=1S/C34H34N2O6/c1-22-27(13-8-14-29(22)26-11-5-4-6-12-26)21-41-28-16-31(40-3)30(19-36-33(23(2)37)34(38)39)32(17-28)42-20-25-10-7-9-24(15-25)18-35/h4-17,23,33,36-37H,19-21H2,1-3H3,(H,38,39)/t23-,33+/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.30n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...


US Patent US9850225 (2017)


BindingDB Entry DOI: 10.7270/Q2N018TZ
More data for this
Ligand-Target Pair