BindingDB logo
myBDB logout

BDBM36412 CID25093486::N-(4-Methylquinolin-8-yl)-4-(endo-4-aza-3,5-dioxotricyclo[5.2.1.02,6]oct-8-en-4-yl)benzamide, 2

SMILES: [H][C@]12C[C@]([H])(C=C1)c1c(O)n(c(O)c21)-c1ccc(cc1)C(=O)Nc1cccc2c(C)ccnc12

InChI Key: InChIKey=KSLHAODJKMKLGY-CALCHBBNSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 36412   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein Wnt


(Mus musculus (Mouse))
BDBM36412
PNG
(CID25093486 | N-(4-Methylquinolin-8-yl)-4-(endo-4-...)
Show SMILES Cc1ccnc2c(NC(=O)c3ccc(cc3)-n3c(O)c4[C@H]5C[C@H](C=C5)c4c3O)cccc12
Show InChI InChI=1S/C26H21N3O3/c1-14-11-12-27-23-19(14)3-2-4-20(23)28-24(30)15-7-9-18(10-8-15)29-25(31)21-16-5-6-17(13-16)22(21)26(29)32/h2-12,16-17,31-32H,13H2,1H3,(H,28,30)/t16-,17+
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 27n/an/an/an/a7.44



University of Texas Southwestern Medical Center



Assay Description
Inhibition assay of Wnt response treated with exogenously supplied of Wnt protein ('exogenous Wnt' test)


Nat Chem Biol 5: 100-7 (2009)


Article DOI: 10.1038/nchembio.137
BindingDB Entry DOI: 10.7270/Q2HX1B20
More data for this
Ligand-Target Pair