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BDBM36414 CID15993586::trans-N-Benzyl-4-((1-((2-cyanophenyl)methyl)-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)methyl)cyclohexanecarboxamide, 4

SMILES: [H][C@]1(Cn2c(=O)n(Cc3ccccc3C#N)c3ccccc3c2=O)CC[C@@]([H])(CC1)C(=O)NCc1ccccc1

InChI Key: InChIKey=JJKQCRYLVDYGDN-RQNOJGIXSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 36414   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein Wnt


(Mus musculus (Mouse))
BDBM36414
PNG
(CID15993586 | trans-N-Benzyl-4-((1-((2-cyanophenyl...)
Show SMILES O=C(NCc1ccccc1)[C@H]1CC[C@H](Cn2c(=O)n(Cc3ccccc3C#N)c3ccccc3c2=O)CC1
Show InChI InChI=1S/C31H30N4O3/c32-18-25-10-4-5-11-26(25)21-34-28-13-7-6-12-27(28)30(37)35(31(34)38)20-23-14-16-24(17-15-23)29(36)33-19-22-8-2-1-3-9-22/h1-13,23-24H,14-17,19-21H2,(H,33,36)/t23-,24-
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PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 25n/an/an/an/a7.44



University of Texas Southwestern Medical Center



Assay Description
Inhibition assay of Wnt response treated with exogenously supplied of Wnt protein ('exogenous Wnt' test)


Nat Chem Biol 5: 100-7 (2009)


Article DOI: 10.1038/nchembio.137
BindingDB Entry DOI: 10.7270/Q2HX1B20
More data for this
Ligand-Target Pair