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BDBM36430 CID25105708::N-(2-(4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)-2-(phenylthio)acetamide, 60

SMILES: O=C(CSc1ccccc1)NCCN1CCC(CC1)n1c2ccccc2[nH]c1=O

InChI Key: InChIKey=DBVPQUXUULCVDM-UHFFFAOYSA-N

Data: 3 IC50  2 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 36430   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM36430
PNG
(CID25105708 | N-(2-(4-(2-Oxo-2,3-dihydro-1H-benzo[...)
Show SMILES O=C(CSc1ccccc1)NCCN1CCC(CC1)n1c2ccccc2[nH]c1=O
Show InChI InChI=1S/C22H26N4O2S/c27-21(16-29-18-6-2-1-3-7-18)23-12-15-25-13-10-17(11-14-25)26-20-9-5-4-8-19(20)24-22(26)28/h1-9,17H,10-16H2,(H,23,27)(H,24,28)
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n/an/a 7.40E+3n/an/an/an/an/a37



Vanderbilt University



Assay Description
PLD in vitro enzymatic assay using phospholipase D1(PLD1).


Nat Chem Biol 5: 108-17 (2009)


Article DOI: 10.1038/nchembio.140
BindingDB Entry DOI: 10.7270/Q2D50KBK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM36430
PNG
(CID25105708 | N-(2-(4-(2-Oxo-2,3-dihydro-1H-benzo[...)
Show SMILES O=C(CSc1ccccc1)NCCN1CCC(CC1)n1c2ccccc2[nH]c1=O
Show InChI InChI=1S/C22H26N4O2S/c27-21(16-29-18-6-2-1-3-7-18)23-12-15-25-13-10-17(11-14-25)26-20-9-5-4-8-19(20)24-22(26)28/h1-9,17H,10-16H2,(H,23,27)(H,24,28)
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n/an/a>2.00E+4n/an/an/an/an/a37



Vanderbilt University



Assay Description
PLD in vitro enzymatic assay using phospholipase D2(PLD2).


Nat Chem Biol 5: 108-17 (2009)


Article DOI: 10.1038/nchembio.140
BindingDB Entry DOI: 10.7270/Q2D50KBK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM36430
PNG
(CID25105708 | N-(2-(4-(2-Oxo-2,3-dihydro-1H-benzo[...)
Show SMILES O=C(CSc1ccccc1)NCCN1CCC(CC1)n1c2ccccc2[nH]c1=O
Show InChI InChI=1S/C22H26N4O2S/c27-21(16-29-18-6-2-1-3-7-18)23-12-15-25-13-10-17(11-14-25)26-20-9-5-4-8-19(20)24-22(26)28/h1-9,17H,10-16H2,(H,23,27)(H,24,28)
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n/an/an/an/a>2.00E+4n/an/an/a37



Vanderbilt University



Assay Description
cell-based assay using HEK293-gfpPLD2 cell line


Nat Chem Biol 5: 108-17 (2009)


Article DOI: 10.1038/nchembio.140
BindingDB Entry DOI: 10.7270/Q2D50KBK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM36430
PNG
(CID25105708 | N-(2-(4-(2-Oxo-2,3-dihydro-1H-benzo[...)
Show SMILES O=C(CSc1ccccc1)NCCN1CCC(CC1)n1c2ccccc2[nH]c1=O
Show InChI InChI=1S/C22H26N4O2S/c27-21(16-29-18-6-2-1-3-7-18)23-12-15-25-13-10-17(11-14-25)26-20-9-5-4-8-19(20)24-22(26)28/h1-9,17H,10-16H2,(H,23,27)(H,24,28)
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n/an/an/an/a 380n/an/an/a37



Vanderbilt University



Assay Description
cell-based assay using human non-small-cell lung cancer cell line, Calu-1


Nat Chem Biol 5: 108-17 (2009)


Article DOI: 10.1038/nchembio.140
BindingDB Entry DOI: 10.7270/Q2D50KBK
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM36430
PNG
(CID25105708 | N-(2-(4-(2-Oxo-2,3-dihydro-1H-benzo[...)
Show SMILES O=C(CSc1ccccc1)NCCN1CCC(CC1)n1c2ccccc2[nH]c1=O
Show InChI InChI=1S/C22H26N4O2S/c27-21(16-29-18-6-2-1-3-7-18)23-12-15-25-13-10-17(11-14-25)26-20-9-5-4-8-19(20)24-22(26)28/h1-9,17H,10-16H2,(H,23,27)(H,24,28)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>2.00E+4n/an/an/an/an/a37



Vanderbilt University



Assay Description
Phopholipase D1(PLD)enzymatic inhibition assay using PLD1.d311


Nat Chem Biol 5: 108-17 (2009)


Article DOI: 10.1038/nchembio.140
BindingDB Entry DOI: 10.7270/Q2D50KBK
More data for this
Ligand-Target Pair