BDBM364431 2-fluoro-5-(1-methyl-1H-pyrazol-3- yl)-N-(2-phenyl-2H-pyrazolo[4,3- b]pyridin-3-yl)-4- (trifluoromethyl)benzamide::US9862707, Example 5

SMILES Cn1ccc(n1)-c1cc(C(=O)Nc2n(nc3cccnc23)-c2ccccc2)c(F)cc1C(F)(F)F

InChI Key InChIKey=CMLHXMMFTDDLSH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 364431   

TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM364431(2-fluoro-5-(1-methyl-1H-pyrazol-3- yl)-N-(2-phenyl...)
Affinity DataIC50:  0.660nMAssay Description:Inhibition of recombinant full length human TRKA expressed in U2OS cells using Poly(Glu:Tyr) as substrate after 30 mins by scintillation counting ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM364431(2-fluoro-5-(1-methyl-1H-pyrazol-3- yl)-N-(2-phenyl...)
Affinity DataIC50:  0.660nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent