BDBM364434 2-fluoro-N-(5-methoxy-2-phenyl- 2H-pyrazolo[4,3-b]pyridin-3-yl)-5- pyrimidin-2-yl-4- (trifluoromethyl)benzamide::US9862707, Example 8

SMILES OCc1ccc2nn(c(NC(=O)c3cc(-c4ncccn4)c(cc3F)C(F)(F)F)c2n1)-c1ccccc1

InChI Key InChIKey=ITZLPHSULOBASY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 364434   

TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM364434(2-fluoro-N-(5-methoxy-2-phenyl- 2H-pyrazolo[4,3-b]...)
Affinity DataIC50:  18nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent