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BDBM364647 US9862730, Example 106

SMILES: COc1ccc2c(C)c(oc2c1)-c1cn2nc(SC)sc2n1

InChI Key: InChIKey=TZRSKOQWYJAJLU-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 364647   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364647
PNG
(US9862730, Example 106)
Show SMILES COc1ccc2c(C)c(oc2c1)-c1cn2nc(SC)sc2n1
Show InChI InChI=1S/C15H13N3O2S2/c1-8-10-5-4-9(19-2)6-12(10)20-13(8)11-7-18-14(16-11)22-15(17-18)21-3/h4-7H,1-3H3
Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 13.9n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)


BindingDB Entry DOI: 10.7270/Q2X92DKF
More data for this
Ligand-Target Pair