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BDBM364754 (R)- and (S)-6-(4,6-Dichlorobenzofuran-2-yl)-2-(1-fluoroethyl)imidazo[2,1-b][1,3,4]thiadiazole::US9862730, Example 213A::US9862730, Example 213B

SMILES: C[C@H](F)c1nn2cc(nc2s1)-c1cc2c(Cl)cc(Cl)cc2o1

InChI Key: InChIKey=LPUNCLDVAIJMDW-LURJTMIESA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 364754   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364754
PNG
((R)- and (S)-6-(4,6-Dichlorobenzofuran-2-yl)-2-(1-...)
Show SMILES C[C@H](F)c1nn2cc(nc2s1)-c1cc2c(Cl)cc(Cl)cc2o1
Show InChI InChI=1S/C14H8Cl2FN3OS/c1-6(17)13-19-20-5-10(18-14(20)22-13)12-4-8-9(16)2-7(15)3-11(8)21-12/h2-6H,1H3/t6-/m0/s1
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UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 10.3n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)


BindingDB Entry DOI: 10.7270/Q2X92DKF
More data for this
Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4)


(Homo sapiens (Human))
BDBM364754
PNG
((R)- and (S)-6-(4,6-Dichlorobenzofuran-2-yl)-2-(1-...)
Show SMILES C[C@H](F)c1nn2cc(nc2s1)-c1cc2c(Cl)cc(Cl)cc2o1
Show InChI InChI=1S/C14H8Cl2FN3OS/c1-6(17)13-19-20-5-10(18-14(20)22-13)12-4-8-9(16)2-7(15)3-11(8)21-12/h2-6H,1H3/t6-/m0/s1
Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 333n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The FLIPR assay is an exemplary in vitro assay for measuring the activity of the PAR4 antagonists of the present invention. In this assay, intracellu...


US Patent US9862730 (2018)


BindingDB Entry DOI: 10.7270/Q2X92DKF
More data for this
Ligand-Target Pair