BDBM365487 US10533001, Example 203::US9868729, Example 203

SMILES: NC(=O)c1cnc(Nc2ccc(cc2)C(=O)NCCO)nc1NC1CC1

InChI Key: InChIKey=RYSKCTAISSFRBM-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 365487   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM365487 (US10533001, Example 203 | US9868729, Example 203) Show SMILES NC(=O)c1cnc(Nc2ccc(cc2)C(=O)NCCO)nc1NC1CC1 Show InChI InChI=1S/C17H20N6O3/c18-14(25)13-9-20-17(23-15(13)21-11-5-6-11)22-12-3-1-10(2-4-12)16(26)19-7-8-24/h1-4,9,11,24H,5-8H2,(H2,18,25)(H,19,26)(H2,20,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
PORTOLA PHARMACEUTICALS, INC. US Patent					Assay Description Syk and JAK: The activity of a specified compound as an inhibitor of a JAK kinase may be assessed in vitro or in vivo. In some embodiments, the activ...				US Patent US10533001 (2020) BindingDB Entry DOI: 10.7270/Q2Z03BJR
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM365487 (US10533001, Example 203 | US9868729, Example 203) Show SMILES NC(=O)c1cnc(Nc2ccc(cc2)C(=O)NCCO)nc1NC1CC1 Show InChI InChI=1S/C17H20N6O3/c18-14(25)13-9-20-17(23-15(13)21-11-5-6-11)22-12-3-1-10(2-4-12)16(26)19-7-8-24/h1-4,9,11,24H,5-8H2,(H2,18,25)(H,19,26)(H2,20,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Portola Pharmaceuticals Inc US Patent					Assay Description SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....				US Patent US9868729 (2018) BindingDB Entry DOI: 10.7270/Q28K7CDJ
					More data for this Ligand-Target Pair