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BDBM365487 US10533001, Example 203::US9868729, Example 203

SMILES: NC(=O)c1cnc(Nc2ccc(cc2)C(=O)NCCO)nc1NC1CC1

InChI Key: InChIKey=RYSKCTAISSFRBM-UHFFFAOYSA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 365487   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365487
PNG
(US10533001, Example 203 | US9868729, Example 203)
Show SMILES NC(=O)c1cnc(Nc2ccc(cc2)C(=O)NCCO)nc1NC1CC1
Show InChI InChI=1S/C17H20N6O3/c18-14(25)13-9-20-17(23-15(13)21-11-5-6-11)22-12-3-1-10(2-4-12)16(26)19-7-8-24/h1-4,9,11,24H,5-8H2,(H2,18,25)(H,19,26)(H2,20,21,22,23)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/an/a



PORTOLA PHARMACEUTICALS, INC.

US Patent


Assay Description
Syk and JAK: The activity of a specified compound as an inhibitor of a JAK kinase may be assessed in vitro or in vivo. In some embodiments, the activ...


US Patent US10533001 (2020)


BindingDB Entry DOI: 10.7270/Q2Z03BJR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM365487
PNG
(US10533001, Example 203 | US9868729, Example 203)
Show SMILES NC(=O)c1cnc(Nc2ccc(cc2)C(=O)NCCO)nc1NC1CC1
Show InChI InChI=1S/C17H20N6O3/c18-14(25)13-9-20-17(23-15(13)21-11-5-6-11)22-12-3-1-10(2-4-12)16(26)19-7-8-24/h1-4,9,11,24H,5-8H2,(H2,18,25)(H,19,26)(H2,20,21,22,23)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/an/a



Portola Pharmaceuticals Inc

US Patent


Assay Description
SYK tyrosine phosphorylation activity is measured using the LANCE™ Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.)....


US Patent US9868729 (2018)


BindingDB Entry DOI: 10.7270/Q28K7CDJ
More data for this
Ligand-Target Pair