BDBM366439 4-[[8-[(9aS)-4-oxo- 6,7,9,9a-tetrahydro- 1H-pyrazino[2,1- c][1,4]oxazin-8-yl]- [1,2,4]triazolo[1,5- a]pyridin-2-yl]amino]- N-methyl-N-(1- methyl-4- piperidyl)benzamide::US9873709, Example 1-32

SMILES CN(C1CCN(C)CC1)C(=O)c1ccc(Nc2nc3c(cccn3n2)N2CCN3[C@H](COCC3=O)C2)cc1

InChI Key InChIKey=OKDGURHZEFKHOU-QFIPXVFZSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 366439   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM366439(4-[[8-[(9aS)-4-oxo- 6,7,9,9a-tetrahydro- 1H-pyrazi...)
Affinity DataKi:  28.8nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM366439(4-[[8-[(9aS)-4-oxo- 6,7,9,9a-tetrahydro- 1H-pyrazi...)
Affinity DataKi:  109nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent