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BDBM369257 N-[4-[6-[1-(cyclopropanecarbonyl)-3,6- dihydro-2H-pyridin-4-yl]thieno[3,2- d]pyrimidin-4- yl]phenyl]cyclopropanesulfonamide::US10227357, Compound P-0571

SMILES: O=C(C1CC1)N1CCC(=CC1)c1cc2ncnc(-c3ccc(NS(=O)(=O)C4CC4)cc3)c2s1

InChI Key: InChIKey=KMUQDSCCWKNLFU-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 369257   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369257
PNG
(N-[4-[6-[1-(cyclopropanecarbonyl)-3,6- dihydro-2H-...)
Show SMILES O=C(C1CC1)N1CCC(=CC1)c1cc2ncnc(-c3ccc(NS(=O)(=O)C4CC4)cc3)c2s1
Show InChI InChI=1S/C24H24N4O3S2/c29-24(17-1-2-17)28-11-9-15(10-12-28)21-13-20-23(32-21)22(26-14-25-20)16-3-5-18(6-4-16)27-33(30,31)19-7-8-19/h3-6,9,13-14,17,19,27H,1-2,7-8,10-12H2
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM369257
PNG
(N-[4-[6-[1-(cyclopropanecarbonyl)-3,6- dihydro-2H-...)
Show SMILES O=C(C1CC1)N1CCC(=CC1)c1cc2ncnc(-c3ccc(NS(=O)(=O)C4CC4)cc3)c2s1
Show InChI InChI=1S/C24H24N4O3S2/c29-24(17-1-2-17)28-11-9-15(10-12-28)21-13-20-23(32-21)22(26-14-25-20)16-3-5-18(6-4-16)27-33(30,31)19-7-8-19/h3-6,9,13-14,17,19,27H,1-2,7-8,10-12H2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)

More data for this
Ligand-Target Pair