BindingDB logo
myBDB logout

BDBM369305 4-[6-(1,3-dimethylpyrazol-4-yl)thieno[3,2- d]pyrimidin-4-yl]-N-[(4- fluorophenyl)methyl]piperazine-1- carboxamide::US10227357, Compound P-0619

SMILES: Cc1nn(C)cc1-c1cc2ncnc(N3CCN(CC3)C(=O)NCc3ccc(F)cc3)c2s1

InChI Key: InChIKey=LIJRWGTWPYHSBZ-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 369305   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM369305
PNG
(4-[6-(1,3-dimethylpyrazol-4-yl)thieno[3,2- d]pyrim...)
Show SMILES Cc1nn(C)cc1-c1cc2ncnc(N3CCN(CC3)C(=O)NCc3ccc(F)cc3)c2s1
Show InChI InChI=1S/C23H24FN7OS/c1-15-18(13-29(2)28-15)20-11-19-21(33-20)22(27-14-26-19)30-7-9-31(10-8-30)23(32)25-12-16-3-5-17(24)6-4-16/h3-6,11,13-14H,7-10,12H2,1-2H3,(H,25,32)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
500n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1FZW
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM369305
PNG
(4-[6-(1,3-dimethylpyrazol-4-yl)thieno[3,2- d]pyrim...)
Show SMILES Cc1nn(C)cc1-c1cc2ncnc(N3CCN(CC3)C(=O)NCc3ccc(F)cc3)c2s1
Show InChI InChI=1S/C23H24FN7OS/c1-15-18(13-29(2)28-15)20-11-19-21(33-20)22(27-14-26-19)30-7-9-31(10-8-30)23(32)25-12-16-3-5-17(24)6-4-16/h3-6,11,13-14H,7-10,12H2,1-2H3,(H,25,32)
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
5.50E+3n/an/an/an/an/an/an/an/a



Plexxikon Inc.

US Patent


Assay Description
The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...


US Patent US10227357 (2019)


BindingDB Entry DOI: 10.7270/Q2HX1FZW
More data for this
Ligand-Target Pair