BDBM369305 4-[6-(1,3-dimethylpyrazol-4-yl)thieno[3,2- d]pyrimidin-4-yl]-N-[(4- fluorophenyl)methyl]piperazine-1- carboxamide::US10227357, Compound P-0619

SMILES: Cc1nn(C)cc1-c1cc2ncnc(N3CCN(CC3)C(=O)NCc3ccc(F)cc3)c2s1

InChI Key: InChIKey=LIJRWGTWPYHSBZ-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 369305   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Kit (Kit)(D816V) (Homo sapiens (Human))	BDBM369305 (4-[6-(1,3-dimethylpyrazol-4-yl)thieno[3,2- d]pyrim...) Show SMILES Cc1nn(C)cc1-c1cc2ncnc(N3CCN(CC3)C(=O)NCc3ccc(F)cc3)c2s1 Show InChI InChI=1S/C23H24FN7OS/c1-15-18(13-29(2)28-15)20-11-19-21(33-20)22(27-14-26-19)30-7-9-31(10-8-30)23(32)25-12-16-3-5-17(24)6-4-16/h3-6,11,13-14H,7-10,12H2,1-2H3,(H,25,32)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...				US Patent US10227357 (2019) BindingDB Entry DOI: 10.7270/Q2HX1FZW
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM369305 (4-[6-(1,3-dimethylpyrazol-4-yl)thieno[3,2- d]pyrim...) Show SMILES Cc1nn(C)cc1-c1cc2ncnc(N3CCN(CC3)C(=O)NCc3ccc(F)cc3)c2s1 Show InChI InChI=1S/C23H24FN7OS/c1-15-18(13-29(2)28-15)20-11-19-21(33-20)22(27-14-26-19)30-7-9-31(10-8-30)23(32)25-12-16-3-5-17(24)6-4-16/h3-6,11,13-14H,7-10,12H2,1-2H3,(H,25,32)	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...				US Patent US10227357 (2019) BindingDB Entry DOI: 10.7270/Q2HX1FZW
					More data for this Ligand-Target Pair