BDBM369338 N-[4-[6-(2-methoxy-4-pyridyl)-7H- pyrrolo[2,3-d]pyrimidin-4-yl]cyclohex-3- en-1-yl]-4- (trifluoromethoxy)benzenesulfonamide::US10227357, Compound P-0654

SMILES COc1cc(ccn1)-c1cc2c(ncnc2[nH]1)C1=CCC(CC1)NS(=O)(=O)c1ccc(OC(F)(F)F)cc1

InChI Key

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 369338   

TargetMast/stem cell growth factor receptor Kit [D816V](Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM369338(N-[4-[6-(2-methoxy-4-pyridyl)-7H- pyrrolo[2,3-d]py...)
Affinity DataKi:  500nMAssay Description:The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM369338(N-[4-[6-(2-methoxy-4-pyridyl)-7H- pyrrolo[2,3-d]py...)
Affinity DataKi:  1.05E+5nMAssay Description:The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent