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BDBM371144 US10239843, Example 251

SMILES: COCCCn1c2ccc(cc2c(=O)n(Cc2cc(C)no2)c1=O)S(=O)(=O)NC1(C)CC1

InChI Key: InChIKey=VCVSXHJMEZNZPY-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 371144   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371144
PNG
(US10239843, Example 251)
Show SMILES COCCCn1c2ccc(cc2c(=O)n(Cc2cc(C)no2)c1=O)S(=O)(=O)NC1(C)CC1
Show InChI InChI=1S/C21H26N4O6S/c1-14-11-15(31-22-14)13-25-19(26)17-12-16(32(28,29)23-21(2)7-8-21)5-6-18(17)24(20(25)27)9-4-10-30-3/h5-6,11-12,23H,4,7-10,13H2,1-3H3
PDB

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PC cid
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US Patent
n/an/a 392n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)


BindingDB Entry DOI: 10.7270/Q21R6SSM
More data for this
Ligand-Target Pair