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BDBM371376 1-Chloro-N-(1-methylcyclopropyl)isoquinoline-7-sulfonamide::US10239843, Example 484

SMILES: CC1(CC1)NS(=O)(=O)c1ccc2ccnc(Cl)c2c1

InChI Key: InChIKey=HJSXARKGWKUBAJ-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 371376   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
poly(ADP-ribose) glycohydrolase (PARG)


(Homo sapiens (Human))
BDBM371376
PNG
(1-Chloro-N-(1-methylcyclopropyl)isoquinoline-7-sul...)
Show SMILES CC1(CC1)NS(=O)(=O)c1ccc2ccnc(Cl)c2c1
Show InChI InChI=1S/C13H13ClN2O2S/c1-13(5-6-13)16-19(17,18)10-3-2-9-4-7-15-12(14)11(9)8-10/h2-4,7-8,16H,5-6H2,1H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.12E+3n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...


US Patent US10239843 (2019)


BindingDB Entry DOI: 10.7270/Q21R6SSM
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM371376
PNG
(1-Chloro-N-(1-methylcyclopropyl)isoquinoline-7-sul...)
Show SMILES CC1(CC1)NS(=O)(=O)c1ccc2ccnc(Cl)c2c1
Show InChI InChI=1S/C13H13ClN2O2S/c1-13(5-6-13)16-19(17,18)10-3-2-9-4-7-15-12(14)11(9)8-10/h2-4,7-8,16H,5-6H2,1H3
PDB
MMDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>1.50E+5n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
PARP1 In vitro selectivity assays were conducted as a 10 ul reaction volume in a NUNC Maxisorp 384-well assay plate pre-coated in-house with Histones...


US Patent US10239843 (2019)


BindingDB Entry DOI: 10.7270/Q21R6SSM
More data for this
Ligand-Target Pair
ADP-ribose glycohydrolase ARH3


(Homo sapiens (Human))
BDBM371376
PNG
(1-Chloro-N-(1-methylcyclopropyl)isoquinoline-7-sul...)
Show SMILES CC1(CC1)NS(=O)(=O)c1ccc2ccnc(Cl)c2c1
Show InChI InChI=1S/C13H13ClN2O2S/c1-13(5-6-13)16-19(17,18)10-3-2-9-4-7-15-12(14)11(9)8-10/h2-4,7-8,16H,5-6H2,1H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>1.50E+5n/an/an/an/an/an/a



Cancer Research Technology Limited

US Patent


Assay Description
ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...


US Patent US10239843 (2019)


BindingDB Entry DOI: 10.7270/Q21R6SSM
More data for this
Ligand-Target Pair