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BDBM372275 8-methyl-4- (pyrrolidin-1-yl) pyrido[3',2':4,5]thieno [3,2-d]pyrimidine::US10239887, Cpd. No. 15

SMILES: Cc1cnc2sc3c(ncnc3c2c1)N1CCCC1

InChI Key: InChIKey=WNVHONNDYZZMQU-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 372275   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Muscarinic acetylcholine receptor M4


(RAT)
BDBM372275
PNG
(8-methyl-4- (pyrrolidin-1-yl) pyrido[3',2':4,5]thi...)
Show SMILES Cc1cnc2sc3c(ncnc3c2c1)N1CCCC1
Show InChI InChI=1S/C14H14N4S/c1-9-6-10-11-12(19-14(10)15-7-9)13(17-8-16-11)18-4-2-3-5-18/h6-8H,2-5H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)


BindingDB Entry DOI: 10.7270/Q2W09880
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372275
PNG
(8-methyl-4- (pyrrolidin-1-yl) pyrido[3',2':4,5]thi...)
Show SMILES Cc1cnc2sc3c(ncnc3c2c1)N1CCCC1
Show InChI InChI=1S/C14H14N4S/c1-9-6-10-11-12(19-14(10)15-7-9)13(17-8-16-11)18-4-2-3-5-18/h6-8H,2-5H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 161n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)


BindingDB Entry DOI: 10.7270/Q2W09880
More data for this
Ligand-Target Pair