BindingDB logo
myBDB logout

BDBM372331 N-cyclopropyl-3,4- dimethyl-pyrimido [4',5':4,5]furo[2,3- c]pyridazin-8-amine::US10239887, Cpd. No. 68

SMILES: Cc1nnc2oc3c(NC4CC4)ncnc3c2c1C

InChI Key: InChIKey=YMXTUBVGNAAKRW-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 372331   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))
BDBM372331
PNG
(N-cyclopropyl-3,4- dimethyl-pyrimido [4',5':4,5]fu...)
Show SMILES Cc1nnc2oc3c(NC4CC4)ncnc3c2c1C
Show InChI InChI=1S/C13H13N5O/c1-6-7(2)17-18-13-9(6)10-11(19-13)12(15-5-14-10)16-8-3-4-8/h5,8H,3-4H2,1-2H3,(H,14,15,16)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.31E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...


US Patent US10239887 (2019)


BindingDB Entry DOI: 10.7270/Q2W09880
More data for this
Ligand-Target Pair