BDBM373008 US10597366, Compound 163::US9896418, Compound 163

SMILES: CS(=O)(=O)c1ccc(c2c1[C@@H](C(C2)(F)F)O)Oc3cc(cc(c3)F)C#N

InChI Key: InChIKey=ONBSHRSJOPSEGS-UHFFFAOYSA-N

Data: 14 IC50  1 Kd  8 EC50

PDB links: 2 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 373008   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Endothelial PAS domain-containing protein 1 (Human)	BDBM373008 (US9896418, Compound 163 | US10597366, Compound 163) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	41	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Endothelial PAS domain-containing protein 1 (Human)	BDBM373008 (US9896418, Compound 163 | US10597366, Compound 163) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Endothelial PAS domain-containing protein 1 (Human)	BDBM373008 (US9896418, Compound 163 | US10597366, Compound 163) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
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Endothelial PAS domain-containing protein 1 (Human)	BDBM373008 (US9896418, Compound 163 | US10597366, Compound 163) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Endothelial PAS domain-containing protein 1 (Human)	BDBM373008 (US9896418, Compound 163 | US10597366, Compound 163) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	46	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Endothelial PAS domain-containing protein 1 (Human)	BDBM373008 (US9896418, Compound 163 | US10597366, Compound 163) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	27	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Endothelial PAS domain-containing protein 1 (Human)	BDBM373008 (US9896418, Compound 163 | US10597366, Compound 163) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 3A4 (Human)	BDBM373008 (US9896418, Compound 163 | US10597366, Compound 163) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2C9 (Human)	BDBM373008 (US9896418, Compound 163 | US10597366, Compound 163) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2B6 (Human)	BDBM373008 (US9896418, Compound 163 | US10597366, Compound 163) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 1A2 (Human)	BDBM373008 (US9896418, Compound 163 | US10597366, Compound 163) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Endothelial PAS domain-containing protein 1 (Human)	BDBM373008 (US9896418, Compound 163 | US10597366, Compound 163) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor A (Human)	BDBM373008 (US9896418, Compound 163 | US10597366, Compound 163) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	42	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Endothelial PAS domain-containing protein 1 (Human)	BDBM373008 (US9896418, Compound 163 | US10597366, Compound 163) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	27	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Endothelial PAS domain-containing protein 1 (Human)	BDBM373008 (US9896418, Compound 163 | US10597366, Compound 163) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	158	n/a	n/a	n/a	n/a
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Cytochrome P450 2C19 (Human)	BDBM373008 (US9896418, Compound 163 | US10597366, Compound 163) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2D6 (Human)	BDBM373008 (US9896418, Compound 163 | US10597366, Compound 163) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2C8 (Human)	BDBM373008 (US9896418, Compound 163 | US10597366, Compound 163) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Human)	BDBM373008 (US9896418, Compound 163 | US10597366, Compound 163) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	42	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Endothelial PAS domain-containing protein 1 (Human)	BDBM373008 (US9896418, Compound 163 | US10597366, Compound 163) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Endothelial PAS domain-containing protein 1 (Human)	BDBM373008 (US9896418, Compound 163 | US10597366, Compound 163) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Endothelial PAS domain-containing protein 1 (Human)	BDBM373008 (US9896418, Compound 163 | US10597366, Compound 163) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Human)	BDBM373008 (US9896418, Compound 163 | US10597366, Compound 163) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	42	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair