BDBM373040 US10597366, Compound 289::US9896418, Compound 289

SMILES: CS(=O)(=O)c1ccc(c2c1[C@@H]([C@@H]([C@@H]2F)F)O)Oc3cc(cc(c3)F)C#N

InChI Key: InChIKey=LOMMPXLFBTZENJ-UHFFFAOYSA-N

Data: 3 IC50  5 EC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 373040   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor A (Human)	BDBM373040 (US9896418, Compound 289 | US10597366, Compound 289) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	18	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor A (Human)	BDBM373040 (US9896418, Compound 289 | US10597366, Compound 289) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	18	n/a	n/a	n/a	n/a
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Endothelial PAS domain-containing protein 1 (Human)	BDBM373040 (US9896418, Compound 289 | US10597366, Compound 289) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor A (Human)	BDBM373040 (US9896418, Compound 289 | US10597366, Compound 289) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	18	n/a	n/a	n/a	n/a
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Endothelial PAS domain-containing protein 1 (Human)	BDBM373040 (US9896418, Compound 289 | US10597366, Compound 289) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
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Endothelial PAS domain-containing protein 1 (Human)	BDBM373040 (US9896418, Compound 289 | US10597366, Compound 289) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	11	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM373040 (US9896418, Compound 289 | US10597366, Compound 289) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Endothelial PAS domain-containing protein 1 (Human)	BDBM373040 (US9896418, Compound 289 | US10597366, Compound 289) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	17	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair