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BDBM373112 1-(2- phenylimidazo[1,2- a]pyridin-3-yl)-3-[2- (1H-pyrazol-1- yl)imidazo[1,2- a]pyridin-3-yl]urea::US9896447, Compound 29

SMILES: O=C(Nc1c(nc2ccccn12)-c1ccccc1)Nc1c(nc2ccccn12)-n1cccn1

InChI Key: InChIKey=JSVRIQKXEWUKQJ-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 373112   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM373112
PNG
(1-(2- phenylimidazo[1,2- a]pyridin-3-yl)-3-[2- (1H...)
Show SMILES O=C(Nc1c(nc2ccccn12)-c1ccccc1)Nc1c(nc2ccccn12)-n1cccn1
Show InChI InChI=1S/C24H18N8O/c33-24(29-22-23(32-16-8-13-25-32)27-19-12-5-7-15-31(19)22)28-21-20(17-9-2-1-3-10-17)26-18-11-4-6-14-30(18)21/h1-16H,(H2,28,29,33)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.40E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells are express TrkA receptor as a fusion with the we...


US Patent US9896447 (2018)

More data for this
Ligand-Target Pair