BDBM373979 5-chloro-4-(((S)-1-((R)-2,3-dihydro-1H-inden-1-yl)pyrrolidin-3-yl)(methyl)amino)-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide 2,2,2-trifluoroacetate::US10246453, Example 246

SMILES: CN([C@H]1CCN(C1)[C@@H]1CCc2ccccc12)c1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1

InChI Key: InChIKey=LHOQAADZGRIBMK-OXJNMPFZSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 373979   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373979 (5-chloro-4-(((S)-1-((R)-2,3-dihydro-1H-inden-1-yl)...) Show SMILES CN([C@H]1CCN(C1)[C@@H]1CCc2ccccc12)c1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1 Show InChI InChI=1S/C23H24ClFN4O2S2/c1-28(16-8-9-29(12-16)20-7-6-15-4-2-3-5-17(15)20)21-11-19(25)22(10-18(21)24)33(30,31)27-23-13-32-14-26-23/h2-5,10-11,13-14,16,20,27H,6-9,12H2,1H3/t16-,20+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	629	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc US Patent					Assay Description This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...				US Patent US10246453 (2019) BindingDB Entry DOI: 10.7270/Q2HM5BRC
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM373979 (5-chloro-4-(((S)-1-((R)-2,3-dihydro-1H-inden-1-yl)...) Show SMILES CN([C@H]1CCN(C1)[C@@H]1CCc2ccccc12)c1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1 Show InChI InChI=1S/C23H24ClFN4O2S2/c1-28(16-8-9-29(12-16)20-7-6-15-4-2-3-5-17(15)20)21-11-19(25)22(10-18(21)24)33(30,31)27-23-13-32-14-26-23/h2-5,10-11,13-14,16,20,27H,6-9,12H2,1H3/t16-,20+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	1.87E+4	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc US Patent					Assay Description This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...				US Patent US10246453 (2019) BindingDB Entry DOI: 10.7270/Q2HM5BRC
					More data for this Ligand-Target Pair
Sodium channel alpha subunits; brain (Types I, II, III) (Homo sapiens (Human))	BDBM373979 (5-chloro-4-(((S)-1-((R)-2,3-dihydro-1H-inden-1-yl)...) Show SMILES CN([C@H]1CCN(C1)[C@@H]1CCc2ccccc12)c1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1 Show InChI InChI=1S/C23H24ClFN4O2S2/c1-28(16-8-9-29(12-16)20-7-6-15-4-2-3-5-17(15)20)21-11-19(25)22(10-18(21)24)33(30,31)27-23-13-32-14-26-23/h2-5,10-11,13-14,16,20,27H,6-9,12H2,1H3/t16-,20+/m0/s1	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...				US Patent US10246453 (2019) BindingDB Entry DOI: 10.7270/Q2HM5BRC
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM373979 (5-chloro-4-(((S)-1-((R)-2,3-dihydro-1H-inden-1-yl)...) Show SMILES CN([C@H]1CCN(C1)[C@@H]1CCc2ccccc12)c1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1 Show InChI InChI=1S/C23H24ClFN4O2S2/c1-28(16-8-9-29(12-16)20-7-6-15-4-2-3-5-17(15)20)21-11-19(25)22(10-18(21)24)33(30,31)27-23-13-32-14-26-23/h2-5,10-11,13-14,16,20,27H,6-9,12H2,1H3/t16-,20+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	1.03E+3	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...				US Patent US10246453 (2019) BindingDB Entry DOI: 10.7270/Q2HM5BRC
					More data for this Ligand-Target Pair
Sodium channel alpha subunits; brain (Types I, II, III) (Homo sapiens (Human))	BDBM373979 (5-chloro-4-(((S)-1-((R)-2,3-dihydro-1H-inden-1-yl)...) Show SMILES CN([C@H]1CCN(C1)[C@@H]1CCc2ccccc12)c1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1 Show InChI InChI=1S/C23H24ClFN4O2S2/c1-28(16-8-9-29(12-16)20-7-6-15-4-2-3-5-17(15)20)21-11-19(25)22(10-18(21)24)33(30,31)27-23-13-32-14-26-23/h2-5,10-11,13-14,16,20,27H,6-9,12H2,1H3/t16-,20+/m0/s1	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	8.51E+3	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc US Patent					Assay Description This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...				US Patent US10246453 (2019) BindingDB Entry DOI: 10.7270/Q2HM5BRC
					More data for this Ligand-Target Pair