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BDBM374248 US10246456, Example 389

SMILES: CCC[C@H](N)c1cccc(n1)-c1cc(-c2cc(C)n(C)n2)c2cnn(-c3cccc(CO)n3)c2c1

InChI Key: InChIKey=UAEPFSWMPFWHGI-ANBDAQEENA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 374248   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374248
PNG
(US10246456, Example 389)
Show SMILES CCC[C@H](N)c1cccc(n1)-c1cc(-c2cc(C)n(C)n2)c2cnn(-c3cccc(CO)n3)c2c1
Show InChI InChI=1/C27H29N7O/c1-4-7-22(28)24-10-6-9-23(31-24)18-13-20(25-12-17(2)33(3)32-25)21-15-29-34(26(21)14-18)27-11-5-8-19(16-35)30-27/h5-6,8-15,22,35H,4,7,16,28H2,1-3H3/t22-/s2
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MMDB

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PC cid
PC sid
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US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)

More data for this
Ligand-Target Pair