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BDBM374430 5-(1-(4-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-3-amine::US10246456, Example 39::US10577367, Example 39

SMILES: Cc1ccnc(c1)-n1ncc2ccc(cc12)-c1cncc(N)c1

InChI Key: InChIKey=DWKAHYYWXQZGJQ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 374430   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374430
PNG
(5-(1-(4-methylpyridin-2-yl)-1H-indazol-6-yl)pyridi...)
Show SMILES Cc1ccnc(c1)-n1ncc2ccc(cc12)-c1cncc(N)c1
Show InChI InChI=1S/C18H15N5/c1-12-4-5-21-18(6-12)23-17-8-13(2-3-14(17)10-22-23)15-7-16(19)11-20-9-15/h2-11H,19H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10577367 (2020)


BindingDB Entry DOI: 10.7270/Q2765HRT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM374430
PNG
(5-(1-(4-methylpyridin-2-yl)-1H-indazol-6-yl)pyridi...)
Show SMILES Cc1ccnc(c1)-n1ncc2ccc(cc12)-c1cncc(N)c1
Show InChI InChI=1S/C18H15N5/c1-12-4-5-21-18(6-12)23-17-8-13(2-3-14(17)10-22-23)15-7-16(19)11-20-9-15/h2-11H,19H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US10246456 (2019)


BindingDB Entry DOI: 10.7270/Q2CV4M12
More data for this
Ligand-Target Pair