BDBM374727 (7S,13R)-11-fluoro-7,13-dimethyl-6,7,13,14- tetrahydro-1,15-ethenopyrazolo[4,3- f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)- one::US10246466, Example 93::US10618912, Example 93::US11291667, Compound 1

SMILES: C[C@H]1CNC(=O)c2cnn3c2nc(cc3)N[C@@H](c4cc(ccc4O1)F)C

InChI Key: InChIKey=FIKPXCOQUIZNHB-UHFFFAOYSA-N

Data: 58 IC50  4 Kd

PDB links: 2 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 78 hits for monomerid = 374727   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
NT-3 growth factor receptor (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.0500	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.830	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.480	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
NT-3 growth factor receptor (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.110	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.0700	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
NT-3 growth factor receptor (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.0700	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.830	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	64	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<0.200	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.0500	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
NT-3 growth factor receptor (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.0500	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.830	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.0700	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
BDNF/NT-3 growth factors receptor (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.440	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4 (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS [G2032R] (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.01	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.170	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
NT-3 growth factor receptor (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.550	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM374727 (US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair