BDBM374791 US10246467, Example I-111::US10919913, # I-111

SMILES Cc1c(ccc2nn3[C@H]4[C@@H](COc3c12)N(CC1CC1)[C@@]1([C@@H]4c2cccc(Cl)c2F)C(=O)Nc2cc(Cl)ccc12)C(O)=O

InChI Key InChIKey=BEGADGRKUSCXTH-OVRLWXHPSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 374791   

TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM374791(US10246467, Example I-111 | US10919913, # I-111)
Affinity DataIC50:  617nMAssay Description:This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117](Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM374791(US10246467, Example I-111 | US10919913, # I-111)
Affinity DataIC50:  617nMAssay Description:This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent