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BDBM3749 N-cyclohexyl-5H-pyrimido[5,4-b]indol-4-amine::Pyrimido[5,4-b]indole deriv. 40

SMILES: C1CCC(CC1)Nc1ncnc2c3ccccc3[nH]c12

InChI Key: InChIKey=SVDCFDHUJJDEPO-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 3749   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM3749
PNG
(N-cyclohexyl-5H-pyrimido[5,4-b]indol-4-amine | Pyr...)
Show SMILES C1CCC(CC1)Nc1ncnc2c3ccccc3[nH]c12
Show InChI InChI=1S/C16H18N4/c1-2-6-11(7-3-1)19-16-15-14(17-10-18-16)12-8-4-5-9-13(12)20-15/h4-5,8-11,20H,1-3,6-7H2,(H,17,18,19)
PDB
MMDB

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PC sid
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Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/a7.422



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair