BDBM374922 (R)-azetidin-1-yl(5-(2-(5- fluoropyridin-3-yl)pyrrolidin-1- yl)pyrazolo[1,5-a]pyrimidin-3- yl)methanone::US10251889, Example 126

SMILES Fc1cncc(c1)C1CCCN1c1ccn2ncc(C(=O)N3CCC3)c2n1

InChI Key InChIKey=CJXSUHUGXGYYSY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 374922   

TargetTyrosine-protein kinase JAK2(Human)
Array Biopharm

US Patent
LigandPNGBDBM374922((R)-azetidin-1-yl(5-(2-(5- fluoropyridin-3-yl)pyrr...)
Affinity DataIC50: 218nMAssay Description:Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Array Biopharm

US Patent
LigandPNGBDBM374922((R)-azetidin-1-yl(5-(2-(5- fluoropyridin-3-yl)pyrr...)
Affinity DataIC50: 1.00E+3nMAssay Description:An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent