BDBM374925 5-((R)-2-(5-fluoropyridin-3- yl)pyrrolidin-1-yl)-N-((R)-1,1,1- trifluoropropan-2-yl)pyrazolo[1,5- a]pyrimidine-3-carboxamide::US10251889, Example 129

SMILES C[C@@H](NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cncc(F)c1)C(F)(F)F

InChI Key InChIKey=KJYXTMLZCPHUAV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 374925   

TargetTyrosine-protein kinase JAK2(Human)
Array Biopharm

US Patent
LigandPNGBDBM374925(5-((R)-2-(5-fluoropyridin-3- yl)pyrrolidin-1-yl)-N...)
Affinity DataIC50: 8nMAssay Description:Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Array Biopharm

US Patent
LigandPNGBDBM374925(5-((R)-2-(5-fluoropyridin-3- yl)pyrrolidin-1-yl)-N...)
Affinity DataIC50: 1.00E+3nMAssay Description:An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent