BDBM374981 (R)-5-(2-(5-fluoro-2-methylpyridin- 3-yl)pyrrolidin-1-yl)-N-(1- methylcyclopropyl)pyrazolo[1,5- a]pyrimidine-3-carboxamide::US10251889, Example 190

SMILES Cc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NC3(C)CC3)c2n1

InChI Key InChIKey=OXVCBPXLNVQEGM-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 374981   

TargetTyrosine-protein kinase JAK2(Human)
Array Biopharm

US Patent
LigandPNGBDBM374981((R)-5-(2-(5-fluoro-2-methylpyridin- 3-yl)pyrrolidi...)
Affinity DataIC50: 2.40nMAssay Description:Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Array Biopharm

US Patent
LigandPNGBDBM374981((R)-5-(2-(5-fluoro-2-methylpyridin- 3-yl)pyrrolidi...)
Affinity DataIC50: 2.40nMAssay Description:Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Array Biopharm

US Patent
LigandPNGBDBM374981((R)-5-(2-(5-fluoro-2-methylpyridin- 3-yl)pyrrolidi...)
Affinity DataIC50: 1.00E+3nMAssay Description:Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Array Biopharm

US Patent
LigandPNGBDBM374981((R)-5-(2-(5-fluoro-2-methylpyridin- 3-yl)pyrrolidi...)
Affinity DataIC50: 1.00E+3nMAssay Description:Compounds of Formula I were screened for their ability to inhibit Jak3 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Array Biopharm

US Patent
LigandPNGBDBM374981((R)-5-(2-(5-fluoro-2-methylpyridin- 3-yl)pyrrolidi...)
Affinity DataIC50: 1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Array Biopharm

US Patent
LigandPNGBDBM374981((R)-5-(2-(5-fluoro-2-methylpyridin- 3-yl)pyrrolidi...)
Affinity DataIC50: 1.00E+3nMAssay Description:Compounds of Formula I were screened for their ability to inhibit Jak1 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Array Biopharm

US Patent
LigandPNGBDBM374981((R)-5-(2-(5-fluoro-2-methylpyridin- 3-yl)pyrrolidi...)
Affinity DataIC50: 1.00E+3nMAssay Description:An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent