BDBM375198 6-{[(6-chloro-2-oxo-1,2-::US10253015, Compound I-58

SMILES: Cc1c(ccc(n1)NCC2=Cc3cc(ccc3NC2=O)Cl)C#N

InChI Key: InChIKey=BPIFALCAPCGTGS-UHFFFAOYSA-N

Data: 11 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 375198   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Isocitrate dehydrogenase [NADP] cytoplasmic [R132H] (Human)	BDBM375198 (6-{[(6-chloro-2-oxo-1,2- | US10253015, Compound I-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
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Isocitrate dehydrogenase [NADP] cytoplasmic [R132C] (Human)	BDBM375198 (6-{[(6-chloro-2-oxo-1,2- | US10253015, Compound I-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic [R132H] (Human)	BDBM375198 (6-{[(6-chloro-2-oxo-1,2- | US10253015, Compound I-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic [R132C] (Human)	BDBM375198 (6-{[(6-chloro-2-oxo-1,2- | US10253015, Compound I-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (Human)	BDBM375198 (6-{[(6-chloro-2-oxo-1,2- | US10253015, Compound I-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (Human)	BDBM375198 (6-{[(6-chloro-2-oxo-1,2- | US10253015, Compound I-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	219	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (Human)	BDBM375198 (6-{[(6-chloro-2-oxo-1,2- | US10253015, Compound I-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.21E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (Human)	BDBM375198 (6-{[(6-chloro-2-oxo-1,2- | US10253015, Compound I-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	274	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (Human)	BDBM375198 (6-{[(6-chloro-2-oxo-1,2- | US10253015, Compound I-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	258	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (Human)	BDBM375198 (6-{[(6-chloro-2-oxo-1,2- | US10253015, Compound I-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	72	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (Human)	BDBM375198 (6-{[(6-chloro-2-oxo-1,2- | US10253015, Compound I-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	820	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (Human)	BDBM375198 (6-{[(6-chloro-2-oxo-1,2- | US10253015, Compound I-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	72	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair