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BDBM376315 (R)-N-(3-(3- hydroxypyrrolidine- 1-carbonyl)benzyl)- 5H-chromeno[3,4-c] pyridine-8- carboxamide::US9914740, III-15

SMILES: O[C@@H]1CCN(C1)C(=O)c1cccc(CNC(=O)c2ccc-3c(OCc4cnccc-34)c2)c1

InChI Key: InChIKey=SMXKKBCFKUVUNL-HXUWFJFHSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 376315   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM376315
PNG
((R)-N-(3-(3- hydroxypyrrolidine- 1-carbonyl)benzyl...)
Show SMILES O[C@@H]1CCN(C1)C(=O)c1cccc(CNC(=O)c2ccc-3c(OCc4cnccc-34)c2)c1
Show InChI InChI=1S/C25H23N3O4/c29-20-7-9-28(14-20)25(31)18-3-1-2-16(10-18)12-27-24(30)17-4-5-22-21-6-8-26-13-19(21)15-32-23(22)11-17/h1-6,8,10-11,13,20,29H,7,9,12,14-15H2,(H,27,30)/t20-/m1/s1
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US Patent
n/an/a 191n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...


US Patent US9914740 (2018)


BindingDB Entry DOI: 10.7270/Q2RX9FCG
More data for this
Ligand-Target Pair