BindingDB logo
myBDB logout

BDBM376724 N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-(isopropyl(methyl)amino)quinoline-8-carboxamide::US10450296, Example 56::US9920032, Example 56

SMILES: CC(C)N(C)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1

InChI Key: InChIKey=KPPMOLQYSWHNQV-KSZLIROESA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 376724   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376724
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES CC(C)N(C)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C26H32FN5O/c1-15(2)32(4)19-12-22-23(27)6-5-21(25(22)30-13-19)26(33)31-24-14-29-8-7-20(24)17-9-16(3)10-18(28)11-17/h5-8,12-18H,9-11,28H2,1-4H3,(H,31,33)/t16-,17+,18-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)


BindingDB Entry DOI: 10.7270/Q20G3NF8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM376724
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES CC(C)N(C)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C26H32FN5O/c1-15(2)32(4)19-12-22-23(27)6-5-21(25(22)30-13-19)26(33)31-24-14-29-8-7-20(24)17-9-16(3)10-18(28)11-17/h5-8,12-18H,9-11,28H2,1-4H3,(H,31,33)/t16-,17+,18-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Pim-2 kinase assay—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay buffer (50 m...


US Patent US9920032 (2018)


BindingDB Entry DOI: 10.7270/Q20G3NF8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376724
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES CC(C)N(C)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C26H32FN5O/c1-15(2)32(4)19-12-22-23(27)6-5-21(25(22)30-13-19)26(33)31-24-14-29-8-7-20(24)17-9-16(3)10-18(28)11-17/h5-8,12-18H,9-11,28H2,1-4H3,(H,31,33)/t16-,17+,18-/m0/s1
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376724
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES CC(C)N(C)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C26H32FN5O/c1-15(2)32(4)19-12-22-23(27)6-5-21(25(22)30-13-19)26(33)31-24-14-29-8-7-20(24)17-9-16(3)10-18(28)11-17/h5-8,12-18H,9-11,28H2,1-4H3,(H,31,33)/t16-,17+,18-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM376724
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES CC(C)N(C)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C26H32FN5O/c1-15(2)32(4)19-12-22-23(27)6-5-21(25(22)30-13-19)26(33)31-24-14-29-8-7-20(24)17-9-16(3)10-18(28)11-17/h5-8,12-18H,9-11,28H2,1-4H3,(H,31,33)/t16-,17+,18-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Pim-2 kinase assay-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay buffer (50 m...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376724
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES CC(C)N(C)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C26H32FN5O/c1-15(2)32(4)19-12-22-23(27)6-5-21(25(22)30-13-19)26(33)31-24-14-29-8-7-20(24)17-9-16(3)10-18(28)11-17/h5-8,12-18H,9-11,28H2,1-4H3,(H,31,33)/t16-,17+,18-/m0/s1
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)


BindingDB Entry DOI: 10.7270/Q20G3NF8
More data for this
Ligand-Target Pair