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BDBM376736 N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-3-((R)-2-methylpyrrolidin-1-yl)quinoline-8-carboxamide::US10450296, Example 68::US9920032, Example 68

SMILES: C[C@@H]1CCCN1c1cnc2c(cccc2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1

InChI Key: InChIKey=BQMTYMRMFIONOP-ZSXPUABSSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 376736   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376736
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1CCCN1c1cnc2c(cccc2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C27H33N5O/c1-17-11-20(13-21(28)12-17)23-8-9-29-16-25(23)31-27(33)24-7-3-6-19-14-22(15-30-26(19)24)32-10-4-5-18(32)2/h3,6-9,14-18,20-21H,4-5,10-13,28H2,1-2H3,(H,31,33)/t17-,18+,20+,21-/m0/s1
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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)


BindingDB Entry DOI: 10.7270/Q20G3NF8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM376736
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1CCCN1c1cnc2c(cccc2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C27H33N5O/c1-17-11-20(13-21(28)12-17)23-8-9-29-16-25(23)31-27(33)24-7-3-6-19-14-22(15-30-26(19)24)32-10-4-5-18(32)2/h3,6-9,14-18,20-21H,4-5,10-13,28H2,1-2H3,(H,31,33)/t17-,18+,20+,21-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Pim-2 kinase assay—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay buffer (50 m...


US Patent US9920032 (2018)


BindingDB Entry DOI: 10.7270/Q20G3NF8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376736
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1CCCN1c1cnc2c(cccc2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C27H33N5O/c1-17-11-20(13-21(28)12-17)23-8-9-29-16-25(23)31-27(33)24-7-3-6-19-14-22(15-30-26(19)24)32-10-4-5-18(32)2/h3,6-9,14-18,20-21H,4-5,10-13,28H2,1-2H3,(H,31,33)/t17-,18+,20+,21-/m0/s1
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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376736
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1CCCN1c1cnc2c(cccc2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C27H33N5O/c1-17-11-20(13-21(28)12-17)23-8-9-29-16-25(23)31-27(33)24-7-3-6-19-14-22(15-30-26(19)24)32-10-4-5-18(32)2/h3,6-9,14-18,20-21H,4-5,10-13,28H2,1-2H3,(H,31,33)/t17-,18+,20+,21-/m0/s1
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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM376736
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1CCCN1c1cnc2c(cccc2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C27H33N5O/c1-17-11-20(13-21(28)12-17)23-8-9-29-16-25(23)31-27(33)24-7-3-6-19-14-22(15-30-26(19)24)32-10-4-5-18(32)2/h3,6-9,14-18,20-21H,4-5,10-13,28H2,1-2H3,(H,31,33)/t17-,18+,20+,21-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Pim-2 kinase assay-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay buffer (50 m...


US Patent US10450296 (2019)


BindingDB Entry DOI: 10.7270/Q2MP55J7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376736
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1CCCN1c1cnc2c(cccc2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1S/C27H33N5O/c1-17-11-20(13-21(28)12-17)23-8-9-29-16-25(23)31-27(33)24-7-3-6-19-14-22(15-30-26(19)24)32-10-4-5-18(32)2/h3,6-9,14-18,20-21H,4-5,10-13,28H2,1-2H3,(H,31,33)/t17-,18+,20+,21-/m0/s1
KEGG

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antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)


BindingDB Entry DOI: 10.7270/Q20G3NF8
More data for this
Ligand-Target Pair