BDBM376892 2-cyclopropyl-N-({1-[4-(3-fluorophenoxy)-6-(trifluoromethyl)pyrimidin-2-yl]-4-hydroxypiperidin-4-yl}methyl)acetamide (E22)::US9920053, Example 22

SMILES OC1(CNC(=O)CC2CC2)CCN(CC1)c1nc(Oc2cccc(F)c2)cc(n1)C(F)(F)F

InChI Key InChIKey=TWCQYNMGGXBODD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 376892   

TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Chronos Therapeutics

US Patent
LigandPNGBDBM376892(2-cyclopropyl-N-({1-[4-(3-fluorophenoxy)-6-(triflu...)
Affinity DataIC50:  26.3nMAssay Description:The affinity of the compounds of the invention to the human DAT or NET or SERT transporters is assessed by using the [3H]WIN-35,428 or [3H]nisoxetine...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Chronos Therapeutics

US Patent
LigandPNGBDBM376892(2-cyclopropyl-N-({1-[4-(3-fluorophenoxy)-6-(triflu...)
Affinity DataIC50: <1.00E+5nMAssay Description:The affinity of the compounds of the invention to the human DAT or NET or SERT transporters is assessed by using the [3H]WIN-35,428 or [3H]nisoxetine...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Chronos Therapeutics

US Patent
LigandPNGBDBM376892(2-cyclopropyl-N-({1-[4-(3-fluorophenoxy)-6-(triflu...)
Affinity DataIC50:  1.74E+3nMAssay Description:The affinity of the compounds of the invention to the human DAT or NET or SERT transporters is assessed by using the [3H]WIN-35,428 or [3H]nisoxetine...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent