BindingDB logo
myBDB logout

BDBM377163 5-Amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-7-cyano-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide::US10265307, Example 18-1::US10517858, Example 18 (Diastereoisomer 1)

SMILES: N[C@H]1CCCN(C1)c1c2CC[C@H](C#N)c2ncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F

InChI Key: InChIKey=QLLAOUOYSHXDOH-OLZOCXBDSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 377163   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM377163
PNG
(5-Amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-7-cyano-...)
Show SMILES N[C@H]1CCCN(C1)c1c2CC[C@H](C#N)c2ncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C24H23F2N7OS/c25-15-4-1-5-16(26)18(15)24-32-20(22(29)35-24)23(34)31-17-10-30-19-12(9-27)6-7-14(19)21(17)33-8-2-3-13(28)11-33/h1,4-5,10,12-13H,2-3,6-8,11,28-29H2,(H,31,34)/t12-,13+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10265307 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K39
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM377163
PNG
(5-Amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-7-cyano-...)
Show SMILES N[C@H]1CCCN(C1)c1c2CC[C@H](C#N)c2ncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C24H23F2N7OS/c25-15-4-1-5-16(26)18(15)24-32-20(22(29)35-24)23(34)31-17-10-30-19-12(9-27)6-7-14(19)21(17)33-8-2-3-13(28)11-33/h1,4-5,10,12-13H,2-3,6-8,11,28-29H2,(H,31,34)/t12-,13+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10265307 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K39
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM377163
PNG
(5-Amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-7-cyano-...)
Show SMILES N[C@H]1CCCN(C1)c1c2CC[C@H](C#N)c2ncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C24H23F2N7OS/c25-15-4-1-5-16(26)18(15)24-32-20(22(29)35-24)23(34)31-17-10-30-19-12(9-27)6-7-14(19)21(17)33-8-2-3-13(28)11-33/h1,4-5,10,12-13H,2-3,6-8,11,28-29H2,(H,31,34)/t12-,13+/m1/s1
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.84 compound/DMSO in the assay buffer (...


US Patent US10517858 (2019)


BindingDB Entry DOI: 10.7270/Q2XD1422
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM377163
PNG
(5-Amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-7-cyano-...)
Show SMILES N[C@H]1CCCN(C1)c1c2CC[C@H](C#N)c2ncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C24H23F2N7OS/c25-15-4-1-5-16(26)18(15)24-32-20(22(29)35-24)23(34)31-17-10-30-19-12(9-27)6-7-14(19)21(17)33-8-2-3-13(28)11-33/h1,4-5,10,12-13H,2-3,6-8,11,28-29H2,(H,31,34)/t12-,13+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.84 compound/DMSO in the assay buffer (...


US Patent US10517858 (2019)


BindingDB Entry DOI: 10.7270/Q2XD1422
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM377163
PNG
(5-Amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-7-cyano-...)
Show SMILES N[C@H]1CCCN(C1)c1c2CC[C@H](C#N)c2ncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C24H23F2N7OS/c25-15-4-1-5-16(26)18(15)24-32-20(22(29)35-24)23(34)31-17-10-30-19-12(9-27)6-7-14(19)21(17)33-8-2-3-13(28)11-33/h1,4-5,10,12-13H,2-3,6-8,11,28-29H2,(H,31,34)/t12-,13+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Pim-2 kinase assay-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay buffer (50 m...


US Patent US10517858 (2019)


BindingDB Entry DOI: 10.7270/Q2XD1422
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM377163
PNG
(5-Amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-7-cyano-...)
Show SMILES N[C@H]1CCCN(C1)c1c2CC[C@H](C#N)c2ncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C24H23F2N7OS/c25-15-4-1-5-16(26)18(15)24-32-20(22(29)35-24)23(34)31-17-10-30-19-12(9-27)6-7-14(19)21(17)33-8-2-3-13(28)11-33/h1,4-5,10,12-13H,2-3,6-8,11,28-29H2,(H,31,34)/t12-,13+/m1/s1
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US10265307 (2019)


BindingDB Entry DOI: 10.7270/Q2FJ2K39
More data for this
Ligand-Target Pair