BDBM377213 5-Amino-N-{4-[(3S,5R)-3-amino-5-methylpiperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-2-(2,6-difluoro-3-methoxyphenyl)-1,3-thiazole-4-carboxamide::US10265307, Example 54-1::US10517858, Example 54 (Diastereoisomer 1)::US10828290, Example 54 (Diastereoisomer 1)::US11229631, Example 54 Diastereoisomer 1

SMILES COc1ccc(F)c(-c2nc(C(=O)Nc3cnc4[C@@H](O)CCc4c3N3C[C@H](C)C[C@H](N)C3)c(N)s2)c1F

InChI Key InChIKey=PTIVAFQAZIXXLU-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 377213   

TargetSerine/threonine-protein kinase pim-1(Human)
Incyte

US Patent
LigandPNGBDBM377213(US10265307, Example 54-1 | 5-Amino-N-{4-[(3S,5R)-3...)
Affinity DataIC50: 100nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
Incyte

US Patent
LigandPNGBDBM377213(US10265307, Example 54-1 | 5-Amino-N-{4-[(3S,5R)-3...)
Affinity DataIC50: 100nMAssay Description:Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
Incyte

US Patent
LigandPNGBDBM377213(US10265307, Example 54-1 | 5-Amino-N-{4-[(3S,5R)-3...)
Affinity DataIC50: 100nMAssay Description:Pim-2 kinase assay-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay buffer (50 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2022
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-3(Human)
Incyte Holdings

US Patent
LigandPNGBDBM377213(US10265307, Example 54-1 | 5-Amino-N-{4-[(3S,5R)-3...)
Affinity DataIC50: 100nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.84 compound/DMSO in the assay buffer (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-3(Human)
Incyte Holdings

US Patent
LigandPNGBDBM377213(US10265307, Example 54-1 | 5-Amino-N-{4-[(3S,5R)-3...)
Affinity DataIC50: 100nMAssay Description:Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Incyte

US Patent
LigandPNGBDBM377213(US10265307, Example 54-1 | 5-Amino-N-{4-[(3S,5R)-3...)
Affinity DataIC50: 100nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2022
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-3(Human)
Incyte Holdings

US Patent
LigandPNGBDBM377213(US10265307, Example 54-1 | 5-Amino-N-{4-[(3S,5R)-3...)
Affinity DataIC50: 100nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
Incyte

US Patent
LigandPNGBDBM377213(US10265307, Example 54-1 | 5-Amino-N-{4-[(3S,5R)-3...)
Affinity DataIC50: 100nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Incyte

US Patent
LigandPNGBDBM377213(US10265307, Example 54-1 | 5-Amino-N-{4-[(3S,5R)-3...)
Affinity DataIC50: 100nMAssay Description:Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-3(Human)
Incyte Holdings

US Patent
LigandPNGBDBM377213(US10265307, Example 54-1 | 5-Amino-N-{4-[(3S,5R)-3...)
Affinity DataIC50: 100nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2022
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
Incyte

US Patent
LigandPNGBDBM377213(US10265307, Example 54-1 | 5-Amino-N-{4-[(3S,5R)-3...)
Affinity DataIC50: 100nMAssay Description:Pim-2 kinase assay-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay buffer (50 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Incyte

US Patent
LigandPNGBDBM377213(US10265307, Example 54-1 | 5-Amino-N-{4-[(3S,5R)-3...)
Affinity DataIC50: 100nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.84 compound/DMSO in the assay buffer (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2020
Entry Details
US Patent