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BDBM377930 2-ethyl-N-(phenyl(piperidin-4-yl)methyl)thiazole-5-carboxamide::US10266526, Compound 60

SMILES: CCc1ncc(s1)C(=O)NC(C1CCNCC1)c1ccccc1

InChI Key: InChIKey=GHZLJNJUSOSKSB-UHFFFAOYNA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 377930   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM377930
PNG
(2-ethyl-N-(phenyl(piperidin-4-yl)methyl)thiazole-5...)
Show SMILES CCc1ncc(s1)C(=O)NC(C1CCNCC1)c1ccccc1
Show InChI InChI=1/C18H23N3OS/c1-2-16-20-12-15(23-16)18(22)21-17(13-6-4-3-5-7-13)14-8-10-19-11-9-14/h3-7,12,14,17,19H,2,8-11H2,1H3,(H,21,22)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.50E+5n/an/an/an/an/an/a



Epizyme Inc

US Patent


Assay Description
The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....


US Patent US10266526 (2019)

More data for this
Ligand-Target Pair