BDBM378252 N-((1r,4r)-4-(3-aminopropanamido)cyclohexyl)-5-methoxypyrazine-2-carboxamide::US10266526, Compound 383

SMILES: COc1cnc(cn1)C(=O)N[C@H]1CC[C@@H](CC1)NC(=O)CCN

InChI Key: InChIKey=OJQNCDKKZPIRLC-XYPYZODXSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 378252   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone-lysine N-methyltransferase SMYD3 (Homo sapiens (Human))	BDBM378252 (N-((1r,4r)-4-(3-aminopropanamido)cyclohexyl)-5-met...) Show SMILES COc1cnc(cn1)C(=O)N[C@H]1CC[C@@H](CC1)NC(=O)CCN Show InChI InChI=1S/C15H23N5O3/c1-23-14-9-17-12(8-18-14)15(22)20-11-4-2-10(3-5-11)19-13(21)6-7-16/h8-11H,2-7,16H2,1H3,(H,19,21)(H,20,22)/t10-,11-	PDB UniProtKB/SwissProt GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme Inc US Patent					Assay Description The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....				US Patent US10266526 (2019) BindingDB Entry DOI: 10.7270/Q2DJ5HX2
					More data for this Ligand-Target Pair