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BDBM378252 N-((1r,4r)-4-(3-aminopropanamido)cyclohexyl)-5-methoxypyrazine-2-carboxamide::US10266526, Compound 383

SMILES: COc1cnc(cn1)C(=O)N[C@H]1CC[C@@H](CC1)NC(=O)CCN

InChI Key: InChIKey=OJQNCDKKZPIRLC-XYPYZODXSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 378252   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone-lysine N-methyltransferase SMYD3


(Homo sapiens (Human))
BDBM378252
PNG
(N-((1r,4r)-4-(3-aminopropanamido)cyclohexyl)-5-met...)
Show SMILES COc1cnc(cn1)C(=O)N[C@H]1CC[C@@H](CC1)NC(=O)CCN
Show InChI InChI=1S/C15H23N5O3/c1-23-14-9-17-12(8-18-14)15(22)20-11-4-2-10(3-5-11)19-13(21)6-7-16/h8-11H,2-7,16H2,1H3,(H,19,21)(H,20,22)/t10-,11-
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+5n/an/an/an/an/an/a



Epizyme Inc

US Patent


Assay Description
The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....


US Patent US10266526 (2019)


BindingDB Entry DOI: 10.7270/Q2DJ5HX2
More data for this
Ligand-Target Pair