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BDBM378686 1-cyclopropyl-N-{1-[(4-hydroxyphenyl)methyl]azetidin-3-yl}-1H-1,2,3-triazole-4-carboxamide::US10266526, Compound 824

SMILES: Oc1ccc(CN2CC(C2)NC(=O)c2cn(nn2)C2CC2)cc1

InChI Key: InChIKey=RITFLQDETUXYLQ-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 378686   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
N-lysine methyltransferase SMYD2


(Homo sapiens (Human))
BDBM378686
PNG
(1-cyclopropyl-N-{1-[(4-hydroxyphenyl)methyl]azetid...)
Show SMILES Oc1ccc(CN2CC(C2)NC(=O)c2cn(nn2)C2CC2)cc1
Show InChI InChI=1S/C16H19N5O2/c22-14-5-1-11(2-6-14)7-20-8-12(9-20)17-16(23)15-10-21(19-18-15)13-3-4-13/h1-2,5-6,10,12-13,22H,3-4,7-9H2,(H,17,23)
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 882n/an/an/an/an/an/a



Epizyme Inc

US Patent


Assay Description
The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% Bovine Skin Gelatin, and 0.002% Tween20, prepared on...


US Patent US10266526 (2019)


BindingDB Entry DOI: 10.7270/Q2DJ5HX2
More data for this
Ligand-Target Pair