BDBM378991 Preparation of 2-[1-(4-ethoxy-2,6-difluorobenzyl)-1H-indazol-3-yl]-4-(pyridin-4-ylamino)pyrimidin-5-ol::US10266548, Example 3-1

SMILES CCOc1cc(F)c(Cn2nc(-c3ncc(O)c(Nc4ccncc4)n3)c3ccccc23)c(F)c1

InChI Key InChIKey=XULWVADMVGBPJU-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 378991   

TargetMitotic checkpoint serine/threonine-protein kinase BUB1(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM378991(Preparation of 2-[1-(4-ethoxy-2,6-difluorobenzyl)-...)
Affinity DataIC50:  4.70nMAssay Description:Bub1-inhibitory activities of compounds described in the present invention were quantified using a time-resolved fluorescence energy transfer (TR-FRE...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent