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BDBM379086 Preparation of 4-({2-[1-(2-fluorobenzyl)-1H-indazol-3-yl]-5-hydroxypyrimidin-4-yl}amino)pyridine-3-carbonitrile::US10266548, Example 26-1

SMILES: Oc1cnc(nc1Nc1ccncc1C#N)-c1nn(Cc2ccccc2F)c2ccccc12

InChI Key: InChIKey=NBDVQFWOWMQCLS-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 379086   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitotic checkpoint serine/threonine-protein kinase BUB1


(Homo sapiens (Human))
BDBM379086
PNG
(Preparation of 4-({2-[1-(2-fluorobenzyl)-1H-indazo...)
Show SMILES Oc1cnc(nc1Nc1ccncc1C#N)-c1nn(Cc2ccccc2F)c2ccccc12
Show InChI InChI=1S/C24H16FN7O/c25-18-7-3-1-5-15(18)14-32-20-8-4-2-6-17(20)22(31-32)24-28-13-21(33)23(30-24)29-19-9-10-27-12-16(19)11-26/h1-10,12-13,33H,14H2,(H,27,28,29,30)
PDB
MMDB

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antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a 17n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Bub1-inhibitory activities of compounds described in the present invention were quantified using a time-resolved fluorescence energy transfer (TR-FRE...


US Patent US10266548 (2019)


BindingDB Entry DOI: 10.7270/Q2RV0R1M
More data for this
Ligand-Target Pair