BDBM380894 8-[1,2,4]Triazolo[4,3-a]pyridin-6-yl- 3,4-dihydro-1H-pyrano[4,3-c]pyridin- 4-ol, Enantiomer II::US9890171, 100::US9890171, 98

SMILES OC1COCc2c1cncc2-c1ccc2nncn2c1

InChI Key InChIKey=IULPKHYUGMXBPX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 380894   

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM380894(8-[1,2,4]Triazolo[4,3-a]pyridin-6-yl- 3,4-dihydro-...)
Affinity DataIC50: 1.30E+3nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM380894(8-[1,2,4]Triazolo[4,3-a]pyridin-6-yl- 3,4-dihydro-...)
Affinity DataIC50: 2.30E+3nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent