BDBM384810 N-{(R)-cyclopropyl[4- (trifluoromethyl)phenyl-1-methyl}-6- oxo-2-pyrrolidin-1-yl-1,6- dihydropyrimidine-4-carboxamide::US10285989, Example 26

SMILES FC(F)(F)c1ccc(cc1)[C@H](NC(=O)c1cc(=O)[nH]c(n1)N1CCCC1)C1CC1

InChI Key InChIKey=OVUOVGWOEBGFLL-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 384810   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384810(N-{(R)-cyclopropyl[4- (trifluoromethyl)phenyl-1-me...)
Affinity DataKi:  0.340nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384810(N-{(R)-cyclopropyl[4- (trifluoromethyl)phenyl-1-me...)
Affinity DataKi:  1.40nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent