BDBM384863 2-(dimethylamino)-N-{1-[2-methoxy- 4-(trifluoromethyl)phenyl]-1- methylethyl}-6-oxo-1,6- dihydropyrimidine-4-carboxamide::US10285989, Example 79

SMILES COc1cc(ccc1C(C)(C)NC(=O)c1cc(=O)[nH]c(n1)N(C)C)C(F)(F)F

InChI Key InChIKey=JXOLGNKITGHRCW-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 384863   

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384863(2-(dimethylamino)-N-{1-[2-methoxy- 4-(trifluoromet...)
Affinity DataKi:  6.40nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384863(2-(dimethylamino)-N-{1-[2-methoxy- 4-(trifluoromet...)
Affinity DataKi:  7.70nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent