BDBM384871 2-(dimethylamino)-6-oxo-N-{(1R)- 1-[4- (trifluoromethoxy)phenyl]ethyl}- 1,6-dihydropyrimidine-4- carboxamide::US10285989, Example 87

SMILES C[C@@H](NC(=O)c1cc(=O)[nH]c(n1)N(C)C)c1ccc(OC(F)(F)F)cc1

InChI Key InChIKey=STULZICZPKXWQU-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 384871   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384871(2-(dimethylamino)-6-oxo-N-{(1R)- 1-[4- (trifluorom...)
Affinity DataKi:  0.740nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384871(2-(dimethylamino)-6-oxo-N-{(1R)- 1-[4- (trifluorom...)
Affinity DataKi:  1.10nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent