BDBM384891 N-{(1R)-cyclopropyl[4- (trifluoromethoxy)phenyl]methyl}-2- (dimethylamino)-6-oxo-1,6- dihydropyrimidine-4-carboxamide::US10285989, Example 107

SMILES CN(C)c1nc(cc(=O)[nH]1)C(=O)N[C@H](C1CC1)c1ccc(OC(F)(F)F)cc1

InChI Key InChIKey=WXRMJQDPCZWIMD-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 384891   

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384891(N-{(1R)-cyclopropyl[4- (trifluoromethoxy)phenyl]me...)
Affinity DataKi:  0.930nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384891(N-{(1R)-cyclopropyl[4- (trifluoromethoxy)phenyl]me...)
Affinity DataKi:  1.70nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384891(N-{(1R)-cyclopropyl[4- (trifluoromethoxy)phenyl]me...)
Affinity DataKi:  2.20nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent