BDBM391076 US9957264, Example 5-147::methyl 4-(cyanomethyl)-4- (4-oxo-3-((4- (trifluoromethyl) phenyl)amino)-4,5-dihydro- 1H-pyrazolo[4,3-c]pyridin- 1-yl)piperidine-1- carboxylate

SMILES COC(=O)N1CCC(CC#N)(CC1)n1nc(Nc2ccc(cc2)C(F)(F)F)c2c1cc[nH]c2=O

InChI Key InChIKey=OYHKWTXACQCGMR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 391076   

TargetTyrosine-protein kinase JAK1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391076(US9957264, Example 5-147 | methyl 4-(cyanomethyl)-...)
Affinity DataIC50: 0.320nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391076(US9957264, Example 5-147 | methyl 4-(cyanomethyl)-...)
Affinity DataIC50: 2.95nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2020
Entry Details
US Patent