BDBM391080 2-((1R,2R)-2-fluoro-1-(3- ((3-methyl-4-(morpholine- 4-carbonyl)phenyl)amino)- 4-oxo-4,5-dihydro-1H- pyrazolo[4,3-c]pyridin-1- yl)cyclohexyl)acetonitrile (from I-19A)::US9957264, Example 5-151

SMILES Cc1cc(Nc2nn(c3cc[nH]c(=O)c23)[C@@]2(CC#N)CCCC[C@H]2F)ccc1C(=O)N1CCOCC1

InChI Key InChIKey=GUVNMXUCKBQQCC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 391080   

TargetTyrosine-protein kinase JAK1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391080(US9957264, Example 5-151 | 2-((1R,2R)-2-fluoro-1-(...)
Affinity DataIC50: 0.0900nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391080(US9957264, Example 5-151 | 2-((1R,2R)-2-fluoro-1-(...)
Affinity DataIC50: 0.100nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2020
Entry Details
US Patent